MASSOBRIO , Paolo

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Microtransducer arrays, both metal microelectrodes and silicon-based devices, are widely used as neural interfaces to measure, extracellularly, the electrophysiological activity of excitable cells. Starting from the pioneering works at the beginning of the 70's, improvements in manufacture methods, materials, and geometrical shape have been...

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Complex network topologies represent the necessary substrate to support complex brain functions. In this work, we reviewed in vitro neuronal networks coupled to Micro-Electrode Arrays (MEAs) as biological substrate. Networks of dissociated neurons developing in vitro and coupled to MEAs, represent a valid experimental model for studying the...

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A detailed analysis of functional connectivity of in vitro neural networks, as well as the possibility to understand the interplay between topology, structure, function and dynamics, is very important for better understanding how the nervous system represents and stores the information. Thus, we developed an informatics toolbox to infer...

Goal of this work is to present a general approach to estimate functional connectivity in in vitro cortical networks coupled to Micro-Electrode Array (MEAs). Specifically, we developed and optimized a Partial Correlation (PC) based algorithm and we compared it to Cross Correlation (CC) and Transfer Entropy (TE) methods. First, we applied the...

Objective. Our goal is to re-introduce an optimized version of the partial correlation to infer structural connections from functional-effective ones in dissociated neuronal cultures coupled to microelectrode arrays. Approach. We first validate our partialization procedure on in silico networks, mimicking different experimental conditions...