MONTELEONE , Lorenzo

Cancer stem cells (CSCs) are a small cancer cells population inside the tumor bulk which play a crucial role in tumor recurrence, metastatic dissemination and therapy resistance. CSCs are characterized by high antioxidant defences, such as glutathione (GSH), which by maintaining low production of reactive oxygen species (ROS) confers to CSCs...

Chemoresistance is due to multiple factors including the induction of a metabolic adaptation of tumor cells. In fact, in these cells, stress conditions induced by therapies stimulate a metabolic reprogramming which involves the strengthening of various pathways such as glycolysis, glutaminolysis and the pentose phosphate pathway. This metabolic...