2004 (v1)
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M
A
MORETTA , Alessandro
Last name: MORETTA
First name: Alessandro
Institution: UNIGE
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2004 (v1)Publication
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2004 (v1)Publication
Natural killer (NK) cells represent a highly specialized lymphoid population characterized by a potent cytolytic activity against tumor or virally infected cells. Their function is finely regulated by a series of inhibitory or activating receptors. The inhibitory receptors, specific for major histocompatibility complex (MHC) class I molecules,...
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1997 (v1)Publication
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2008 (v1)Publication
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2016 (v1)Publication
Background: PD-1 is an immunologic checkpoint that limits immune responses by delivering potent inhibitory signals to T cells on interaction with specific ligands expressed on tumor/virusinfected cells, thus contributing to immune escape mechanisms. Therapeutic PD-1 blockade has been shown to mediate tumor eradication with impressive clinical...
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2008 (v1)Publication
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2001 (v1)Publication
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2009 (v1)Publication
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2008 (v1)Publication
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2008 (v1)Publication
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2006 (v1)Publication
Natural killer (NK) cells have been known for many years as the lymphocyte subset characterized by the highest cytolytic potential against virus-infected and tumor-transformed cells. A surprisingly high number of surface molecules have been recognized that regulate human NK cell function. These include MHC-specific inhibitory receptors, which...
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2008 (v1)Publication
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1979 (v1)Publication
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1998 (v1)Publication
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2003 (v1)Publication
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2005 (v1)Publication
Human natural killer (NK) cells are equipped with a series of surface receptors that recognise different cellular ligands on potential target cells. Some of these ligands [e.g. human leukocyte antigen (HLA) class I] prevent an NK-mediated attack by interacting with inhibitory NK receptors (e.g. killer Ig-like receptors). Other ligands interact...
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2012 (v1)Publication
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2000 (v1)Publication
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2016 (v1)Publication
Innate and adaptive immunity has evolved complex molecular mechanisms regulating immune cell migration to facilitate the dynamic cellular interactions required for its function involving the chemokines and their receptors. One important chemokine receptor in the immune system is represented by CCR7. Together with its ligands CCL19 and CCL21,...
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2010 (v1)Publication
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2013 (v1)Publication
Killer immunoglobulin-like receptors (KIRs) play an essential role in the regulation of natural killer (NK) activity, allowing NK cells to sense and respond to human leukocyte antigen (HLA) class I downregulation, an important hallmark for viral infections and tumor transformation. KIR and HLA genes are located on different chromosomes and...
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2009 (v1)Publication
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