1998 (v1)
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1998 (v1)Publication
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2009 (v1)Publication
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2009 (v1)Publication
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2004 (v1)Publication
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2004 (v1)Publication
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2004 (v1)Publication
Natural killer (NK) cells represent a highly specialized lymphoid population characterized by a potent cytolytic activity against tumor or virally infected cells. Their function is finely regulated by a series of inhibitory or activating receptors. The inhibitory receptors, specific for major histocompatibility complex (MHC) class I molecules,...
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1997 (v1)Publication
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2008 (v1)Publication
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2008 (v1)Publication
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2006 (v1)Publication
Natural killer (NK) cells have been known for many years as the lymphocyte subset characterized by the highest cytolytic potential against virus-infected and tumor-transformed cells. A surprisingly high number of surface molecules have been recognized that regulate human NK cell function. These include MHC-specific inhibitory receptors, which...
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2008 (v1)Publication
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2001 (v1)Publication
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2009 (v1)Publication
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2008 (v1)Publication
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1979 (v1)Publication
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1998 (v1)Publication
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2003 (v1)Publication
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2005 (v1)Publication
Human natural killer (NK) cells are equipped with a series of surface receptors that recognise different cellular ligands on potential target cells. Some of these ligands [e.g. human leukocyte antigen (HLA) class I] prevent an NK-mediated attack by interacting with inhibitory NK receptors (e.g. killer Ig-like receptors). Other ligands interact...
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2012 (v1)Publication
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2000 (v1)Publication
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2010 (v1)Publication
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2013 (v1)Publication
Killer immunoglobulin-like receptors (KIRs) play an essential role in the regulation of natural killer (NK) activity, allowing NK cells to sense and respond to human leukocyte antigen (HLA) class I downregulation, an important hallmark for viral infections and tumor transformation. KIR and HLA genes are located on different chromosomes and...
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2009 (v1)Publication
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2006 (v1)Publication
Oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides (CpG ODN) mimic the immunostimulatory activity of microbial DNA via Toll-like receptor (TLR)9. Previous studies indicated that human NK cells express functional TLR3 and TLR9, since their cytokine release and cytolytic function could be incremented by poly(I:C) or ODN A/B,...
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2005 (v1)Publication
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