MORI , Laura

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Objective: To investigate the possible correlations between clinico-radiological features and pathophysiological mechanisms in patients with dystonia secondary to focal brain lesions. Methods: Single and paired-pulse transcranial magnetic stimulation was used to assess corticospinal excitability in 10 patients (4 females; mean age 61) and a...

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Background.– Previous results in patients injected with abobotulinum toxin A and onabotulinum toxin A have shown that injection intervals shorter than 2 months may increase the risk for neutralising antibody formation and treatment non-response. As a result, for the last 10 years, we have adopted longer intervals to treat patients with...

Stroke is the most disabling neurological disorder and often causes spasticity. Transmucosal cannabinoids (tetrahydrocannabinol and cannabidiol (THC:CBD), Sativex) is currently available to treat spasticity-associated symptoms in patients with multiple sclerosis. Cannabinoids are being considered useful also in the treatment of pain, nausea and...

BACKGROUND: Recent studies demonstrated the usefulness of radial shock waves therapy (RSWT) in treating hypertonia in patients affected by cerebral palsy (CP), stroke, and dystonia. RSWT have never been used to treat spasticity in disabled athletes. CASE REPORT: An athlete affected by tetraparesis due to CP underwent three RSWT sessions in a...

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In a clinical setting, where motor-driven systems are not readily available, the major difficulty in the assessment of the stretch reflex lies in the control of passive limb displacement velocity. A potential approach to this problem arises from the use of manual sinusoidal movements (made by continuous alternating flexions and extensions)...

Postactivation depression (PaD) refers to the inhibition of the H-reflex induced by a preceding conditioning stimulus able to activate the afferents mediating the H-reflex itself. PaD is thought to depend on intrinsic neuronal properties of the Ia fibres, associated with a decreased probability of transmitter release from the repetitively...