March 25, 2008 (v1)
Journal article
PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.
Cell adaptation to changes in oxygen (O(2)) availability is controlled by two subfamilies of O(2)-dependent enzymes: the hypoxia inducible factor (HIF)-prolyl and asparaginyl hydroxylases [prolyl hydroxylases domain (PHDs) and factor inhibiting HIF (FIH)]. These oxygen sensors regulate the activity of the HIF, a transcriptional complex central...
Uploaded on: December 4, 2022