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MAGGI , E.

Last name: MAGGI

First name: E.

2015 (v1)

Publication

Metadata-only

Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells

Mazzoni, A. Santarlasci, V. Maggi, L.

Th17-derived Th1 lymphocytes, termed nonclassic, differ from classic Th1 cells because of the presence of retinoic acid orphan receptor (ROR)C2 and the surface expression of CD161 and CCR6. We demonstrate in this article that nonclassic Th1 cells, like Th17 cells, have a marked RORC2 and IL17A demethylation, whereas classic Th1 cells exhibit a...

Uploaded on: February 7, 2024