MAGGI , Enrico

Introduction: In the last two decades the knowledge of the mechanisms of the inflammatory processes underlying asthma rapidly evolved, several key mediators (cytokines and receptors) were identified, and the laboratory techniques have allowed us to synthesize monoclonal antibodies highly specific for those target molecules. Nowadays, many...

Background: Protection against helminths consists of adaptive responses by TH2 cells and innate responses by group 2 innate lymphoid cells (ILC2s), with these latter being well characterized in mice but less so in human subjects. Objective: We sought to characterize human circulating ILC2s and compare their functional profile with that of...

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Background: There is little information on the trajectory and developmental fate of Lin(-)CD34(+)DNAM-1(bright) CXCR4(+) progenitors exiting bone marrow during systemic inflammation. Objective: To study Lin(-)CD34(+)DNAM-1(bright) CXCR4(+) cell circulation in cancer patients, to characterize their entry into involved lung tissue and to...