M

J

MAILLET , Julie

Last name: MAILLET

First name: Julie

October 2016 (v1)

Journal article

Metadata-only

DNA damage and the activation of the p53 pathway mediate alterations in metabolic and secretory functions of adipocytes Running title: DNA damage and p53 in obese adipocytes

Vergoni, Bastien Cornejo, Pierre-Jean Gilleron, Jérôme

Activation of the p53 pathway in adipose tissue contributes to insulin resistance associated with obesity. However, the mechanisms of p53 activation and the impact on adipocyte functions are still elusive. Here we found a higher level of DNA oxidation and a reduction in telomere length in adipose tissue of high-fat diet mice and an increase in...

Uploaded on: February 28, 2023