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MANAA , Wejdane El

Last name: MANAA

First name: Wejdane El

November 29, 2022 (v1)

Journal article

Metadata-only

The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production

Afram, Elissa Lauritzen, Inger Bourgeois, Alexandre

Abstract The processing of the amyloid precursor protein (APP) is one of the key events contributing to Alzheimer's disease (AD) etiology. Canonical cleavages by β- and γ-secretases lead to Aβ production which accumulate in amyloid plaques. Recently, the matrix metalloprotease MT5-MMP, referred to as η-secretase, has been identified as a novel...

Uploaded on: September 5, 2023