MANCARDI G. L.

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Background/Objective. Position sense, defined as the ability to identify joint and limb position in space, is crucial for balance and gait but has received limited attention in patients with multiple sclerosis (MS). We investigated lower limb position sense deficits, their neural correlates, and their effects on standing balance in patients...

Introduction. Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by acute or subacute bilateral loss of central vision. A clinical subtype of LHON presents T2-weighted magnetic resonance imaging (MRI) lesions indistinguishable from those of multiple sclerosis (MS) (LHON-MS). Ojectives. To assess the severity of...

A Guillain Barré syndrome is a rare event in the course of MS, in spite of the fact that both disorders are demyelinating and are possibly immune mediated. We present a case of a 45-years-old female with a definite MS of the RR type clinically characterized by an ataxic paraparesis who presented a subacute worsening of the muscolar strenght in...

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Background: Natalizumab is a monoclonal antibody approved for the treatment of patients with relapsing-remitting multiple sclerosis. According to the current clinical recommendations, its use during pregnancy should be carefully evaluated only in women with highly active disease who plan a pregnancy or have an unplanned pregnancy, after...

Background: An engineered glove measuring finger motor performance previously showed ability to discriminate early-stage multiple sclerosis (MS) patients from healthy controls (HCs). Radiologically isolated syndrome (RIS) classifies asymptomatic subjects with brain magnetic resonance imaging (MRI) abnormalities suggestive of multiple sclerosis....