MANDALA M

Baseline neutrophil and derived neutrophil-to-lymphocyte ratio, either alone, or better combined, are significantly and independently associated with progression-free survival and overall survival of metastatic melanoma patients receiving ipilimumab therapy. These factors may serve as objective, inexpensive markers to help risk-group...

Background: Retreatment with ipilimumab has been shown to re-establish disease control in some patients with disease progression. Here, we report the efficacy and safety of retreatment with ipilimumab 3mg kg(-1) among patients participating in an expanded access programme in Italy. Methods: Patients who achieved disease control during induction...