Background: Spasticity in multiple sclerosis (MS) results from an imbalance of inputs from descending pathways to the spinal motor circuits, as well as from a damage of the corticospinal tract (CST). Objectives: To assess CST impairment in MS patients with and without spasticity and to evaluate its evolution under Sativex® treatment. Methods:...
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2017 (v1)PublicationUploaded on: April 14, 2023
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2016 (v1)Publication
Background and purpose: Charcot−Marie−Tooth (CMT) disease is the most common inherited neuropathy, but therapeutic options have been limited to symptom management. Past pharmacological trials have failed, possibly due to insensitive outcome measures (OMs). The aim of the current study was to evaluate the validity and reliability of the 6-min...
Uploaded on: April 14, 2023