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MANOUCHEHRIAN , O.

Last name: MANOUCHEHRIAN

First name: O.

November 24, 2023 (v1)

Publication

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Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

Manouchehrian, O. Ramos, M. Bachiller, Sara

The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is largely dependent on arterial pulsatility and astrocytic aquaporin-4 (AQP4) expression, facilitates much of this brain clearance. During...

Uploaded on: November 27, 2023
July 6, 2022 (v1)

Publication

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Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner

Bachiller, Sara Hidalgo, Isabel Garcia, M. G.

Background The risk of developing Alzheimer's disease (AD) is modulated by genetic and environmental factors. Early-life stress (ELS) exposure during critical periods of brain development can impact later brain function and health, including increasing the risk of developing AD. Microglial dysfunction and neuroinflammation have been implicated...

Uploaded on: December 2, 2022