Aging constitutes the major risk factor for metabolic disabilities onset and cardiovascular disease. Clinically, is associated with an increase in IL1β and IL18, which are cytokines released after inflammasome-dependent caspase-1 activation. This suggests that prevalence and severity of age-related diseases is partly due to chronic inflammasome...
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September 24, 2018 (v1)PublicationUploaded on: March 25, 2023
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March 31, 2020 (v1)Publication
While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely unknown. During aging, many alterations occur in the organism, which are associated with progressive impairment of metabolic pathways related to insulin resistance, autophagy dysfunction, and inflammation. Here, we...
Uploaded on: December 4, 2022 -
September 27, 2017 (v1)Publication
Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose transport and mitochondrial...
Uploaded on: December 4, 2022 -
January 24, 2019 (v1)Publication
Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases. In this study, we investigated the role of AMPK/NLRP3 inflammasome axis in the molecular mechanism underlying pain...
Uploaded on: December 4, 2022