MARAGLIANO L.

Activation of voltage-gated ion channels is regulated by conformational changes of the voltage sensor domains (VSDs), four water- and ion-impermeable modules peripheral to the central, permeable pore domain. Anomalous currents, defined as ω-currents, have been recorded in response to mutations of residues on the VSD S4 helix and associated with...

Claudins are tissue-specific transmembrane proteins able to form junctions between two cells and regulate the flow of physiological solutes parallel to the cell walls, that is, the paracellular transport. Claudin-15 is highly expressed in the intestine where it forms efficient Na + channels and Cl - barriers. However, the molecular details of...

The recent determination of cryo-EM structures of voltage-gated sodium (Nav) channels has revealed many details of these proteins. However, knowledge of ionic permeation through the Navpore remains limited. In this work, we performed atomistic molecular dynamics (MD) simulations to study the structural features of various neuronal Navchannels...