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MARCHALANT , Yannick

Last name: MARCHALANT

First name: Yannick

2014 (v1)

Journal article

Metadata-only

Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP

Py, Nathalie A. Bonnet, Amandine E. Bernard, Anne

Matrix metalloproteinases (MMPs) are pleiotropic endopeptidases involved in a variety of neurodegenerative/neuroinflammatory processes through their interactions with a large number of substrates. Among those, the amyloid precursor protein (APP) and the beta amyloid peptide (Aβ) are largely associated with the development of Alzheimer's disease...

Uploaded on: December 4, 2022
2016 (v1)

Journal article

Metadata-only

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid ă pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease

Baranger, Kévin Marchalant, Yannick Bonnet, Amandine E.

Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology. The implication of MT5-MMP in Alzheimer's disease (AD), notably its interplay with the amyloidogenic process, remains elusive. Accordingly, we crossed the genetically engineered 5xFAD mouse...

Uploaded on: December 4, 2022