M

A

MARCHIANÒ , A

Last name: MARCHIANÒ

First name: A

2014 (v1)

Publication

Metadata-only

PF-03446962, a fully-human monoclonal antibody against transforming growth-factor β (TGFβ) receptor ALK1, in pre-treated patients with urothelial cancer: an open label, single-group, phase 2 trial.

Necchi, A Giannatempo, P Mariani, L

Despite a compelling preclinical rationale for the use of anti-angiogenic drugs in urothelial cancer (UC), short-living responses have been observed in clinical trials. PF-03446962 is a novel monoclonal antibody against Activin Receptor-Like Kinase-1 (ALK1), a type I subclass of the TGF beta receptor, with dose-dependent anti-angiogenic...

Uploaded on: April 14, 2023