MARCILLA , David

Risk stratification of solitary fibrous tumor (SFT) patients based on clinicopathological features has limited efficacy, especially in predicting late relapse or metastasis. The hallmark alteration of SFT is the gene fusion NAB2-STAT6, whose prognostic value remains controversial. As biological knowledge of this entity has increased in recent...

Wilms tumour (WT) is the most common renal tumour in children. Most WT patients respond to chemotherapy, but subsets of tumours develop resistance to chemotherapeutic agents, which is a major obstacle in their successful treatment. Multidrug resistance transporters play a crucial role in the development of resistance in cancer due to the efflux...

YAP1 and TAZ (WWTR1) oncoproteins are thefinal transducers of the Hippo tumor suppressor pathway. Deregula-tion of the pathway leads to YAP1/TAZ activation fostering tumorigenesis in multiple malignant tumor types, includ-ing sarcoma. However, oncogenic mutations within the core components of the Hippo pathway are uncommon.Ewing sarcoma (EwS),...