MARCO MILANESE

Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease characterized by a progressive degeneration of motor neurons (MNs). The etiology is still largely obscure, and several mechanisms have been proposed, including glutamate-mediated excitotoxicity. In this context, group I metabotropic glutamate receptors (mGluR1/5) play an...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by degeneration and death of motor neurons (MNs). ALS is multifactorial and non-cell autonomous disease and astrocytes play a key role in this complex scenario. We previously demonstrated the beneficial outcome of intravenous administration of mesenchymal stem...

Most neurodegenerative disorders have complex and still unresolved pathology characterized by progressive neuronal damage and death. Astrocytes, the most-abundant non-neuronal cell population in the central nervous system, play a vital role in these processes. They are involved in various functions in the brain, such as the regulation of...

No description