MARENGO B.

Epidemiological studies provide evidence that physical activity reduces the risk of cancer, particularly of breast cancer. However, little is known about the underlying molecular mechanisms as related to microRNAs. The goal of the herein presented study is to explore the involvement of miRNAs in beneficial effects exerted by physical activity...

Introduction: The latest GLOBOCAN 2021 reports that colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Most CRC cases are sporadic and associated with several risk factors, including lifestyle habits, gut dysbiosis, chronic inflammation, and oxidative stress. Aim: To summarize the biology of CRC and discuss...

Background/Aims: Whey proteins (WP), obtained from milk after casein precipitation, represent a heterogeneous group of proteins. WP are reported to inhibit food intake in diet-induced experimental obesity; WP have been proposed as adjuvant therapy in oxidative stress-correlated pathologies. This work evaluates the effects of WP in comparison...

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Pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea compounds (STIRUR 13, STIRUR 41 and BUR 12) have been demonstrated to exert a strong inhibitory effect on interleukin 8 or N-formyl-methionyl-leucyl-phenylalanine-induced chemotaxis of human neutrophils. Since the migration of cancer cells is comparable to that of neutrophils, the purpose of...

In chrysotile, the most commercialized asbestos, Fe and other toxic metals are worth considering in its pathogenicity (Gualtieri et al., 2019); in fact, large amounts of Fe (>1000 ppm) and trace metals (Cr, Ni, Co, Mn, ...) are also intimately associated with the raw material. Since both Fe and trace metals are usually isomorphous substituent...

Cancer stem cells (CSCs) are a limited cell population inside a tumor bulk characterized by high levels of glutathione (GSH), the most important antioxidant thiol of which cysteine is the limiting amino acid for GSH biosynthesis. In fact, CSCs over-express xCT, a cystine transporter stabilized on cell membrane through interaction with CD44, a...

In chrysotile, the most commercialized asbestos species, Fe and other metals are worth considering in its potential toxicity (Gualtieri et al., 2019); in fact, large amounts of Fe (>1000 ppm) and trace metals (Cr, Ni, Co, Mn, etc.) are also intimately associated with the raw material. Since both Fe and trace metals are usually isomorphous...