MARIANGELI , M

The genetic condition known as Hutchinson-Gilford Progeria Syndrome (HGPS) causes the early onset of aging symptoms and premature death. HGPS is caused by a single nucleotide mutation in the LMNA gene, resulting in a truncated form of the protein Lamin A known as ΔLA50 or Progerin. This protein modification causes aberrant lamina network...

Enveloped viruses, i.e., comprising a phospholipidic membrane encapsulating their genetic material, are pathogens responsible for many diseases, often severe (e.g., COVID-19 and AIDS). Since the viral envelope has a fundamental role in their infectivity, it may represent a promising target for broad-spectrum antivirals. We are proposing the use...

Optical Nanoscopy deals with designing and developing optical microscopes able to produce images that are rich sources of quantitative information at the nanoscale. This fact offers an unprecedented insight into the molecular mechanisms that govern and determine the fate of living cells, coupled with a large amount of data to be structured. In...

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