MARTÍN CORDERO , Carmen

Los progresos científicos y técnicos aplicados al ámbito vegetal han permitido, desde hace un cierto número de años, identificar los principios activos de las plantas. Cada especie vegetal es bioquímicamente diferente y abarca una serie de variaciones genéticas y ambientales que hacen de la Naturaleza una fuente de moléculas inagotable. La...

The discovery of new topoisomerase I inhibitors is necessary since most of the antitumor drugs are targeted against type II and only a very few can specifically affect type I. Topoisomerase poisons generate toxic DNA damage by stabilization of the covalent DNA-topoisomerase cleavage complex and some have therapeutic efficacy in human cancer....

The phenomenon of today's ageing population has increased interest in the search for new active substances that delay the onset and development of neurodegenerative diseases. In this respect, the search for natural compounds, mainly phenolic compounds, with neuroprotective activity has become the focus of growing interest. Verbascoside is a...

Curcumin, the major active component of the spice turmeric, is recognised as a safe compound with great potential for cancer chemoprevention and cancer therapy. It induces apoptosis, but its initiation mechanism remains poorly understood. Curcumin has been assessed on the human cancer cell lines, TK-10, MCF-7 and UACC62, and their IC50 values...

The therapeutic anticancer potential of flavonoids shown by recent research needs a greater understanding of these compounds. They are antioxidants and antimutagenic agents that can inhibit tumor promotion and transformation and can modify the activity of a large number of mammalian enzyme systems, such as human DNAtopoisomerases. Poisons of...

La presente invención tiene por objeto a un extracto citotóxico procedente de las hojas de Corema album (Ericaceae), así como a sus fracciones y principios activos aislados, que generan especies reactivas de oxígeno (ERO) e inducen apoptosis. También incl

The rhizomes of Acanthus mollis have traditionally been used for the treatment of several ailments involving inflammation. However, to the best of our knowledge, their chemical composition and pharmacological properties have not been studied until now. As a first approach, this study analyses the A. mollis rhizome hexane extract phytochemistry...

To study the cytotoxic activity of P. harmala. Materials and method: The alkaloids harmine and harmaline have been isolated from a methanolic extract from the seeds of P. harmala L. and have been characterized by spectroscopic-Mass and NMR methods. The cytotoxicity of the methanolic extract and both alkaloids has been investigated in the...

The leaves of Corema album (Ericaceae), an endemic shrub which grows in Atlantic coastal areas of the Iberian Peninsula, are rich in flavonoids and other secondary metabolites. Silica gel column chromatography of the ethyl acetate extract from dried leaves was performed and a flavonic active fraction was obtained. The cytotoxic activity of this...

There is currently substantial interest in the cyto-protective effects of natural compounds against oxidative stress and in studying of the defense mechanisms involved. Corema album fruit is an edible berry consumed along the Atlantic littoral of the Iberian Peninsula. The aim of this study was to characterize the phenolic composition and...