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MARTÍNEZ , Antón L.

Last name: MARTÍNEZ

First name: Antón L.

2023 (v1)

Publication

Metadata-only

Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction

Asproni, Battistina Catto, Marco Loriga, Giovanni

A library of eighteen thienocycloalkylpyridazinones was synthesized for human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE) inhibition and serotonin 5-HT6 receptor subtype interaction by following a multitarget-directed ligand approach (MTDL), as a suitable strategy for treatment of Alzheimer's disease (AD). The novel compounds...

Uploaded on: February 14, 2024