MARTÍNEZ FÁBREGAS , Jonathan

La organización celular de los organismos fue descubierta a mediados del siglo XIX por Schwann y Schleiden (1847). Poco tiempo después se puso de manifiesto que la muerte celular representaba una parte esencial del desarrollo animal (Vogt, 1884). Observada en primer lugar durante la metamorfosis de los anfibios (Vogt, 1884), pronto se puso...

More than 50 years have passed since Nobel laureate Cristian de Duve described for the first time the presence of tiny subcellular compartments filled with hydrolytic enzymes: the lysosome. For a long time, lysosomes were deemed simple waste bags exerting a plethora of hydrolytic activities involved in the recycling of biopolymers, and...

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Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed cell death is necessary for development and the hypersensitive response to stress or pathogenic infection. A common feature in programmed cell death across organisms is the translocation of cytochrome c from mitochondria...

Since the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in vitro, the molecular mechanisms involved in its regulation. Although the role of cytochrome c during apoptosis is well-established, relatively little is known about its participation in signaling pathways in vivo due to its...