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MARTÍNEZ GALLEGO , Irene

Last name: MARTÍNEZ GALLEGO

First name: Irene

July 30, 2024 (v1)

Publication

Metadata-only

A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and age-dependent impairments in hippocampal plasticity

Arias-Aragón, Francisco Tristán Clavijo, Enriqueta Martínez Gallego, Irene

Alzheimer's disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical studies have shown decreased expression of the glutamatergic protein Neuroligin-1 (Nlgn1) in AD. However, the consequences of a sustained reduction of Nlgn1 are unknown. Here, we generated a knockin mouse that reproduces the...

Uploaded on: July 31, 2024