MARTÍNEZ SÁNCHEZ , Sara María

Unraveling the relationships between ecological, functional traits and genetic diversity of narrow endemic plants provide opportunities for understanding how evolutionary processes operate over local spatial scales and ultimately how diversity is created and maintained. To explore these aspects in Sierra Nevada, the core of the Mediterranean...

Prognosis of melanoma patients with metastatic disease is very poor. For example, over 95% of melanoma patients with three or more sites of metastatic disease die within 1 year. Treatment failure usually occurs because the drugs used for the treatment of these patients have a low capacity to kill melanoma cells selectively. By using human...

Cancer statistics show that the most commonly diagnosed cancer in the world is lung cancer, that over 50% of patients diagnosed with this cancer have distant metastasis, and that only 4% of these patients manage to survive more than 5 years. The limited selective cytotoxicity of the drugs used for the treatment of these patients probably...

Dadas las amenazas actuales sobre la biodiversidad del planeta, es crítico desentrañar los mecanismos evolutivos responsables de la formación de los puntos calientes de biodiversidad («hotspots»). Sierra Nevada es un «hotspot» en la cuenca mediterránea, donde una compleja historia geológica y climática ha creado diversos hábitats a los que las...