MARTINOIA S.

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Behaviors, from simple to most complex, require a two-way interaction with the environment and the contribution of different brain areas depending on the orchestrated activation of neuronal assemblies. We used cultured networks coupled to MEAs (i.e. Micro Electrode Arrays) as a simplified model system to investigate the computational properties...

Behaviors, from simple to most complex, require a two-way interaction with the environment and the contribution of different brain areas depending on the orchestrated activation of neuronal assemblies. We used cultured networks coupled to MEAs (i.e. Micro Electrode Arrays) as a simplified model system to investigate the computational properties...

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Neuro-electronic interfaces play a fundamental role for studying brain functions and cellular mechanisms of information processing both in vitro and in vivo. Here we present a new concept in which electronic devices are integrated with models of neuronal networks of human origin together with nanotools to characterize the (patho)physiology of...

Since their introduction in the early 1970s, microelectrode arrays (MEAs) have been dominating the electrophysiology market thanks to their reliability, extreme robustness, and usability. Over the past 40 years, silicon technology has also played a role in the advancement of the field, and CMOS-based in vitro and in vivo systems are now able to...

Human-induced pluripotent stem cells (hiPSCs) with their differentiation protocols, constitute a potential tool to investigate the various biological mechanisms of different human cells, such as those of the central nervous system. With the advent of such technique, we have increased the knowledge of biological mechanisms of neural diseases...

Methods for studying brain function and disease heavily rely on in vivo animal models, ex-vivo tissue slices, and 2D cell culture platforms. These methods all have limitations that significantly impact the clinical translatability of results. Consequently, models able to better recapitulate some aspects of in vivo human brain are needed as...

Microelectrode arrays (MEAs) play a crucial role in investigating the electrophysiological activities of neuronal populations. Although two-dimensional neuronal cell cultures have predominated in neurophysiology in monitoring in-vitro the electrophysiological activity, recent research shifted toward culture using three-dimensional (3D) neuronal...

Understanding and discriminating the spatiotemporal patterns of activity generated by in vitro and in vivo neuronal networks is a fundamental task in neuroscience and neuroengineering. The state-of-the-art algorithms to describe the neuronal activity mostly rely on global and local well-established spike and burst-related parameters. However,...

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects ≈6 million people worldwide. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor disability and improves quality of life in patients with advanced PD who have severe levodopa-induced motor complications. Precise targeting of STN regions is...

Objective. In this paper, we report on the development of an easy-to-fabricate three-dimensional Micro-Electrode Array (3D-MEA) specifically designed for brain-on-a-dish applications. Approach. The proposed device consists of pillar-shaped gold microelectrodes realized by electroplating directly on top of a standard MEA, making this approach...