MARY , Arnaud

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. Failures of candidate treatments targeting the beta amyloid (Aβ), a catabolite originating from the amyloid precursor protein (APP), highlight the multifactorial nature of this pathology. Hence, the early defects of mitochondrial structure and functions, and the...

No abstract available

Several lines of recent evidence indicate that the amyloid precursor protein-derived C-terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's disease (AD) pathology. Altered mitochondrial homeostasis is considered an early event in AD development. However, the specific contribution of APP-CTFs to mitochondrial...