MATILDE BALBI

Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non‐cell autonomous neurodegenerative disease characterized by upper and lower motor neuron loss. Several genetic mutations lead to ALS development and many emerging gene mutations have been discovered in recent years. Over the decades since 1990, several animal...

Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent a leading mechanism for excessive synaptic Glu. We demonstrated that group I metabotropic Glu receptors (mGluR1, mGluR5) produced abnormal Glu release in SOD1G93A mouse spinal...

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective death of motoneurons (MNs). ALS is also defined a non-cell-autonomous disease, due to the contribution of glial cells that acquire an aberrant reactive phenotype and secrete neurotoxic factors toward MN. At present there is no effective cure for...

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective death of motoneurons (MNs). Despite significant progress the precise pathological mechanisms of MN death remain largely obscure. ALS is also defined a non-cell-autonomous disease, due to the contribution of glial cells that acquire an...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective death of motoneurons (MNs). Despite significant progress the precise pathological mechanisms of MN death remain largely obscure. ALS is also defined a non-cell-autonomous disease, due to the contribution of glial cells that acquire an...