MAURO MAGNANI

Glutathione derivatives (GSH) of formula (I) are provided, wherein R is a thiol protection group. The derivatives are useful for the treatment of infections from Paramyxovirus, Orthomyxovirus, Herpes Simplex Virus and Acquired Immunodeficiency Syndrome Virus.

In the last years, nanopore technology has been increasingly exploited for biomolecule detection andanalysis. Recently, the main focus of the research has moved from the study of nucleic acids to theanalysis of proteins and DNA-protein complexes. In this paper, chemically functionalized solid-statenanopore has been used to recognize Nuclear...

Sirtuin 6 (SIRT6) is a member of the mammalian NAD+-dependent deac(et)ylase sirtuin family. SIRT6's anti-inflammatory roles are emerging increasingly often in different diseases and cell types, including endothelial cells. In this study, the role of SIRT6 in pro-inflammatory conditions was investigated by engineering human umbilical vein...

Background: presence of NAD in the extracellular environment acts as an autocrine/paracrine signal in different cell types (including smooth myocytes, neurons, human hematopoietic stem cells, granulocytes), mediating inflammatory responses, cell proliferation and neurotransmitter release. Extracellular NAD (eNAD) can trigger cell responses...