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MAY , Lisa A

Last name: MAY

First name: Lisa A

June 24, 2010 (v1)

Journal article

Metadata-only

Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic.

Hughes, Francis M Shaner, Brooke E May, Lisa A

The neurotensin hexapapetide fragment NT(8-13) is a potent analgesic when administered directly to the central nervous system but does not cross the blood-brain barrier. A total of 43 novel derivatives of NT(8-13) were evaluated, with one, ABS212 (1), being most active in four rat models of pain when administered peripherally. Compound 1 binds...

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