MAZZA , Davide

The nucleus is the cellular organelle that harbors the genetic information into DNA, which forms with histone proteins the fundamental unit of chromatin. Chromatin is organized by physical and molecular forces, like phase separation and molecular crowding, into functional domains whose formation and mobility correlate to chromatin compaction...

The architectural organization of chromatin can play an important role in gene expression by regulating the diffusion of molecules via binding interactions and molecular crowding [1]. In this respect, understanding how variations of chromatin architecture affect nuclear dynamics is of fundamental importance. Fluorescence Correlation...

Spinocerebellar ataxia type 28 (SCA28) is a neurodegenerative disease caused by mutations of the mitochondrial protease AFG3L2. The SCA28 mouse model, which is haploinsufficient for Afg3l2, exhibits a progressive decline in motor function and displays dark degeneration of Purkinje cells (PC-DCD) of mitochondrial origin. Here, we determined that...

Objective Trained immunity (TI) is a de facto memory program of innate immune cells, characterized by immunometabolic and epigenetic changes sustaining enhanced production of cytokines. TI evolved as a protective mechanism against infections; however, inappropriate activation can cause detrimental inflammation and might be implicated in the...

The integration of endocytic routes is critical to regulate receptor signaling. A nonclathrin endocytic (NCE) pathway of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations and targets receptors to degradation, attenuating signaling. Here we performed an unbiased molecular characterization of EGFR-NCE. We...