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MAZZOLA , Chiara

Last name: MAZZOLA

First name: Chiara

2018 (v1)

Publication

Metadata-only

Inhibition of chloride intracellular channel 1 (CLIC1) as biguanide class-effect to impair human glioblastoma stem cell viability

Barbieri, Federica Würth, Roberto Pattarozzi, Alessandra

The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to translate in a clinical setting. Consequently, the search for more potent metformin...

Uploaded on: March 27, 2023