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MAZZONI A

Last name: MAZZONI A

2015 (v1)

Publication

Metadata-only

Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells

Mazzoni A Santarlasci V Maggi L

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Uploaded on: April 14, 2023
2014 (v1)

Publication

Metadata-only

IL-4-induced gene 1 maintains high Tob1 expression that contributes to TCR unresponsiveness in human T helper 17 cells

Santarlasci V Maggi L Mazzoni A

Human Th17 cells have a limited proliferative capacity compared to other T-cell subsets. We have shown that human Th17 cells display impaired IL-2 production due to IL-4- induced gene 1 (IL4I1) upregulation. Here, we show that in human Th17 cells, IL4I1 also maintains high levels of Tob1, a member of the Tob/BTG (B-cell traslocation...

Uploaded on: March 27, 2023