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MEDINA , Indira

Last name: MEDINA

First name: Indira

February 4, 2019 (v1)

Publication

Metadata-only

Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility

Bermúdez Pulgarín, Beatriz Medina, Indira Cougoule, Célibe

Background Leukocyte migration is critical for the infiltration of monocytes and accumulation of monocyte derived macrophages in inflammation. Considering that Hck and Fgr are instrumental in this process, their impact on atherosclerosis and on lesion inflammation and stability was evaluated. Methods and Results Hematopoietic...

Uploaded on: March 27, 2023
March 7, 2022 (v1)

Publication

Metadata-only

Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function

Bermúdez Pulgarín, Beatriz Dahl, Tuva Borresdatter Medina, Indira

Objective-Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular NAMPT (iNAMPT), the rate limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD)+ generation, in atherogenesis is largely unknown. Here we investigated...

Uploaded on: December 4, 2022