MEJÍAS NAVARRO , Fernando

La molécula de ADN está permanentemente expuesta a múltiples fuentes de daño que ponen en peligro la integridad genómica. Una de las lesiones más graves son los cortes de doble cadena (DSB, por sus siglas en inglés), que si no son reparados o son reparados incorrectamente, pueden conducir a diversas enfermedades incluido el cáncer. Para...

During repair of DNA double-strand breaks, resection of DNA ends influences how these lesions will be repaired. If resection is activated, the break will be channeled through homologous recombination; if not, it will be simply ligated using the non-homologous end-joining machinery. Regulation of resection relies greatly on modulating CtIP,...

DNA breaks are complex lesions that can be repaired either by non-homologous end joining (NHEJ) or by homologous recombination (HR). The decision between these two routes of DNA repair is a key point of the DNA damage response (DDR) that is controlled by DNA resection. The core machinery catalyzing the resection process is well established....

There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these pathways; in this study we took advantage of the SeeSaw Reporter, in which the repair of double-strand breaks by...