M

C

MEJIA-CARVAJAL , Carmen

Last name: MEJIA-CARVAJAL

First name: Carmen

2014 (v1)

Publication

Metadata-only

Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with Wiskott-Aldrich syndrome

O'Connell, Amy E. Volpi, Stefano Dobbs, Kerry

The Wiskott-Aldrich syndrome (WAS) is due to mutations of the WAS gene encoding for the cytoskeletal WAS protein, leading to abnormal downstream signaling from the T cell and B cell antigen receptors (TCR and BCR). We hypothesized that the impaired signaling through the TCR and BCR in WAS would subsequently lead to aberrations in the immune...

Uploaded on: April 14, 2023