M

MENG X.

Last name: MENG X.

2022 (v1)

Publication

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Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing

Fossa P. Uggeri M. Orro A.

Cystic fibrosis is a hereditary disease mainly caused by the deletion of the Phe 508 (F508del) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is thus withheld in the endoplasmic reticulum and rapidly degraded by the ubiquitin/proteasome system. Cystic fibrosis remains a potentially fatal disease, but it has...

Uploaded on: November 25, 2023
2019 (v1)

Publication

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Exploitation of a novel biosensor based on the full-length human F508del-CFTR with computational study, biochemical and biological assays for the characterization of a new Lumacaftor/Tezacaftor analogue.

D'Ursi P. Uggeri M. Urbinati C.

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Uploaded on: April 14, 2023
2024 (v1)

Publication

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Coronary artery calcification and cardiovascular outcome as assessed by intravascular OCT and artificial intelligence

Tian J. Chao L. I. Zhifeng Q. I. N.

Coronary artery calcification (CAC) is a marker of atherosclerosis and is thought to be associated with worse clinical outcomes. However, evidence from large-scale high-resolution imaging data is lacking. We proposed a novel deep learning method that can automatically identify and quantify CAC in massive intravascular OCT data trained using...

Uploaded on: October 1, 2024