A 114/066(10)
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August 12, 2021 (v1)PublicationUploaded on: March 25, 2023
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November 28, 2022 (v1)Publication
A highly enantio- and diastereoselective thiourea-catalyzed dearomatization of isoquinolines employing N-tert-butylhydrazones as neutral α-azo carbanions and masked acyl anion equivalents has been developed. Experimental and computational data supports the generation of highly ordered complexes wherein the chloride behaves as a template for the...
Uploaded on: December 4, 2022 -
September 21, 2022 (v1)Publication
We report a straightforward synthetic strategy for the preparation of trihydroxypiperidine azasugars decorated with lipophilic chains at both the nitrogen and the adjacent carbon as potential inhibitors of the lysosomal enzyme glucocerebrosidase (GCase), which is involved in Gaucher disease. The procedure relies on the preparation of...
Uploaded on: December 4, 2022