Pregnancy requires a special management in women with inflammatory rheumatic diseases (RDs), with the aim of controlling maternal disease activity and avoiding fetal complications. Despite the heterogeneous course of RDs during pregnancy, their impact on pregnancy largely relates to the extent of active inflammation at the time of conception....
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2019 (v1)PublicationUploaded on: April 14, 2023
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2010 (v1)Publication
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Uploaded on: April 14, 2023 -
2010 (v1)PublicationEstrogens interfere with leflunomide modulation of cytokine production by human activated monocytes.
Rheumatoid arthritis (RA) prevalence is greater in females than in males, supporting estrogens as modulators of immune response. Leflunomide (LEF) is employed in the RA treatment. We studied the combinatory effects of LEF active metabolite A77 1726 (LEF-M) and 17beta-estradiol (E2) on inflammatory cytokine production by cultured macrophages...
Uploaded on: April 14, 2023 -
2011 (v1)PublicationEstrogens interfere with leflunomide modulation of cytokine production by human activated monocytes.
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Uploaded on: April 14, 2023 -
2009 (v1)Publication
Clinical and experimental evidence indicates that rheumatoid arthritis prevalence is greater in females than in males, and supports a role for estrogens as modulators of the immune response. Immunocytochemistry (ICC) showed that the antiproliferative drug Leflunomide (LEF) is successfully employed in rheumatoid arthritis. In this study we...
Uploaded on: April 14, 2023 -
2022 (v1)Publication
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Uploaded on: February 14, 2024