MITHIEUX , Gilles

Gluconeogenesis is induced in both the liver and intestine by increased cAMP levels. However, hepatic and intestinal glucose production can have opposite effects on glucose homeostasis. Glucose release into the portal vein by the intestine increases glucose uptake and reduces food intake. In contrast, glucose production by the liver contributes...

Glycogen storage disease type 1a (GSD1a) is a rare disease due to the deficiency in theglucose-6-phosphatase catalytic subunit (encoded by G6pc), which is essential forendogenous glucose production. Despite strict diet control to maintain blood glucose, patientswith GSD1a develop hepatomegaly, steatosis and then hepatocellular adenomas...

Type 2 diabetes (T2D) and obesity are strongly associated with low natriuretic peptide (NP) plasma levels and a down-regulation of NP guanylyl cyclase receptor-A (GCA) in skeletal muscle and adipose tissue. However, no study has so far provided evidence for a causal link between atrial NP (ANP)/GCA deficiency and T2D pathogenesis. Here, we show...