M

E

MOCAER , E

Last name: MOCAER

First name: E

2018 (v1)

Publication

Metadata-only

The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats

Morley-Fletcher, S Zuena, A R Mairesse, J

S 47445 is a positive modulator of glutamate AMPA-type receptors, possessing neurotrophic and enhancing synaptic plasticity effects as well as pro-cognitive and anti-stress properties. Here, the drug was assessed in the perinatal stress (PRS) rat model, known to have a high predictive validity with monoaminergic antidepressants. The effects of...

Uploaded on: April 14, 2023