MOGNI , Massimo

Background aims.The amniotic fluid is a new source of multipotent stem cells with therapeutic potential for human dis-eases. In agreement with the regulatory requirement to reduce and possibly to avoid animal-derived reagents in the cultureof cells intended for cell therapy, bovine serum, the most common supplement in the culture medium, was...

Human amniotic fluid stem cells (hAFS) have shown a distinct secretory profile and significant regenerative potential in several preclinical models of disease. Nevertheless, little is known about the detailed characterization of their secretome. Herein we show for the first time that hAFS actively release extracellular vesicles (EV) endowed...