No established therapies for patients with hepatocellular carcinoma (HCC) and progression on first-line sorafenib treatment currently exist. This phase I/II trial investigated safety, pharmacokinetics (PK) and potential biomarkers of the deacetylase inhibitor (HDAC) resminostat and a combination therapy with resminostat and sorafenib.
-
2016 (v1)PublicationUploaded on: April 14, 2023
-
2021 (v1)Publication
No description
Uploaded on: April 14, 2023 -
2020 (v1)Publication
BackgroundTocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.MethodsA multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study the effect of tocilizumab on lethality rates at 14 and 30 days...
Uploaded on: March 25, 2023