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MORA , Jaume

Last name: MORA

First name: Jaume

May 18, 2020 (v1)

Publication

Metadata-only

RING1B contributes to Ewing sarcoma development by repressing the Na(V)1.6 sodium channel and the NF-kappa B pathway, independently of the fusion oncoprotein

Hernández Muñoz, Inmaculada Figuerola, Elisabeth Sánchez Molina, Sara

Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate that RING1B is highly expressed in primary ES tumors, and its expression is independent of the fusion oncogene. RING1B-depleted ES cells display an expression profile enriched in genes functionally involved in hematological...

Uploaded on: December 4, 2022
April 20, 2023 (v1)

Publication

Metadata-only

Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies

Sánchez Molina, Sara Figuerola Bou, Elisabet Sánchez Margalet, Víctor

Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. The standard therapy, including chemotherapy, surgery, and radiotherapy, has substantially improved the survival of EWS patients with localized disease. Unfortunately, this multimodal treatment remains elusive in clinics...

Uploaded on: April 23, 2023