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MORANDO , Sara

Last name: MORANDO

First name: Sara

2015 (v1)

Publication

Metadata-only

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

Parodi, Benedetta Rossi, Silvia Morando, Sara

Dimethyl fumarate (DMF), recently approved as an oral immunomodulatory treatment for relapsing-remitting multiple sclerosis (MS), metabolizes to monomethyl fumarate (MMF) which crosses the blood-brain barrier and has demonstrated neuroprotective effects in experimental studies. We postulated that MMF exerts neuroprotective effects through...

Uploaded on: April 14, 2023