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MOREAU , Christophe

Last name: MOREAU

First name: Christophe

December 20, 2021 (v1)

Journal article

Metadata-only

Distinct classes of potassium channels fused to GPCRs as electrical signaling biosensors

García-Fernández, M Dolores Chatelain, Franck Nury, Hugues

Ligand-gated ion channels (LGICs) are natural biosensors generating electrical signals in response to the binding of specific ligands. Creating de novo LGICs for biosensing applications is technically challenging. We have previously designed modified LGICs by linking G protein-coupled receptors (GPCRs) to the Kir6.2 channel. In this article, we...

Uploaded on: December 4, 2022
2023 (v1)

Journal article

Metadata-only

Elucidation of the structural basis for ligand binding and translocation in conserved insect odorant receptor co-receptors

Pacalon, Jody Audic, Guillaume Magnat, Justine

In numerous insects, the olfactory receptor family forms a unique class of heteromeric cation channels. Recent progress in resolving the odorant receptor structures offers unprecedented opportunities for deciphering their molecular mechanisms of ligand recognition. Unexpectedly, these structures in apo or ligand-bound states did not reveal the...

Uploaded on: February 4, 2024