The cytoplasmic b subunit of voltage-dependent calcium channels modulates channel properties in a subtype-specific manner and is important in channel targeting. A high affinity interaction site between the a1interaction domain (AID) in the I-II cytoplasmic loop ofa1 and the b interaction domain (BID) of the b subunit ishighly conserved among...
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April 1999 (v1)Journal articleUploaded on: December 3, 2022
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September 2001 (v1)Journal article
Two C-terminal splice variants (BI-1 and BI-2, now termed Cav2.1a and Cav2.1b) of the neuronal voltage-gated P/Q-type Ca2+channel a1A pore-forming subunit have been cloned (Mori et al., 1991, Nature, 350, 398±402). BI-1 and BI-2 code for proteins of2273 and 2424 amino acids, respectively, and differ only by their extreme carboxyl-termini...
Uploaded on: December 4, 2022 -
January 2000 (v1)Journal article
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Uploaded on: December 3, 2022 -
September 12, 2012 (v1)Journal article
Calcium current through voltage-gated calcium channels (VGCC) controls gene expression. Here, we describe a novel signalling pathway in which the VGCC Cacnb4 subunit directly couples neuronal excitability to transcription. Electrical activity induces Cacnb4 association to Ppp2r5d, a regulatory subunit of PP2A phosphatase, followed by (i)...
Uploaded on: December 3, 2022