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MOSCHKE , Katrin

Last name: MOSCHKE

First name: Katrin

January 10, 2017 (v1)

Journal article

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MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

Baranger, Kévin Bonnet, Amandine E Girard, Stéphane D

We previously reported that deficiency of membrane-type five matrix metalloproteinase (MT5-MMP) prevents amyloid pathology in the cortex and hippocampus of 5xFAD mice, and ameliorates the functional outcome. We have now investigated whether the integrity of another important area affected in Alzheimer's disease (AD), the frontal cortex, was...

Uploaded on: December 4, 2022
2016 (v1)

Journal article

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MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid ă pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease

Baranger, Kévin Marchalant, Yannick Bonnet, Amandine E.

Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology. The implication of MT5-MMP in Alzheimer's disease (AD), notably its interplay with the amyloidogenic process, remains elusive. Accordingly, we crossed the genetically engineered 5xFAD mouse...

Uploaded on: December 4, 2022